Main Cast
- David Kaufman as Danny Fenton/Danny Phantom
- Grey DeLisle-Griffin as Sam Manson
- Rickey D'Shon Collins as Tucker Foley
- Rob Paulsen as Jack Fenton, Box Ghost, and Nicolai Technus
- Kath Soucie as Maddie Fenton
- Colleen O'Shaughnessey as Jazz Fenton
- S. Scott Bullock as Dash Baxter
- Ron Pearlman as Mr. Lancer
- Maria Canals Barrera as Paulina Sanchez
Guest Stars
- Cree Summer as Valerie Gray
- Kevin Michael Richardson as Skulker (2nd voice)
- Tara Strong as Ember McLain and Penelope Spectra
- Dat Phan as Kwan (1st voice)
- James Sie as Kwan (2nd voice)
Special Guests
- Patricia Heaton as Lunch Lady Ghost (1st voice)
- Matthew St. Patrick as Skulker (1st voice)
- Peter MacNicol as Sidney Poindexter
- Peri Gilpin as Desiree
- Martin Mull as Vlad Masters/Vlad Plasmius
- William Baldwin as Johnny 13
- Chynna Phillips as Kitty
- Michael Dorn as Fright Knight
- Jon Cryer as Freakshow
- Brian Cox as Pariah Dark
- David Carradine as Clockwork
- Eric Roberts as Dark Danny
- Will Arnett as Ghost Writer
- Mark Hamill as Undergrowth